i think you can adjust the heel cup so it moves inwards. but, with my angles there isnt much clearance between the edge of my gnu Carbon Credit 162w and the base plates. so my answer would be no.
I double this. I ride a Lib Tech Skunk Ape 165W and have a ton of cuff overhang with toe overhang. I also ride anywhere from 21/21 to 18/18 for my ducked out stance.
Lib Tech Skunk Ape C2 165W '13
Union Holden Collab '12
Burton Ions '14