I am having a real struggle with this debate as well.
1. my '99 Civic SI performs extremely well in snow, has relatively low miles, is EXTREMELY rare (try to buy one), and has lost very little value over time. It's only caveat, why I'm looking at a truck is I need trailworthiness for trailhead access.
2. I drive 30 miles each way to work everyday, and further than that on my days off, so the mileage adds up quick.
3. Does the slight advantage in the toyo mpg worth it for all these miles over an f-150? I do like the f-150 alot. What about a 4cyl toyo? Do they even have that in 4wd?
4. Should I crush my truck dreams because of all these miles, drive my SI into the ground and just get another lil 2wd wonder with snowtires - fuck I'd go hybrid?
Don't know your budget, but there is a new turbo 6 cyl edition of the F150 that really helps with gas mileage, but you get all the perks of the 1/2 ton pickup.