Mendel, which way are you driving up? I lived in Reston, VA for a year and made lots of trips back here to Rochester. If you take Route 15 all the way up and then get on 390 North, it takes you right past Swain. Then you jump on 390 North to 90 West and that takes you to Buffalo. Then you could take 219 South while leaving Buffalo and hit up Holiday Valley, take 86 East back towards Route 15 and take that back to DC.