It really doesn't matter where you stay, as long as it's not Blueberry Hill or Creekside. There's free bus service throughout the entire village area, but the buses cost money once you get outside of the village. Merlin's is one of my favorite apre locations, their nachos are EPIC! GLC has pretty good apre as well and is right next to the Whistler Gondola. I usually steer clear of the clubs on weekends, it's mostly 19 year old dudes trying to hump anything that moves. I usually just stick to the bars along the village stroll.
FYI during a holiday, you'll want to make reservations for almost any time you're eating in the village. The place gets PACKED.
I LOVE Whistler, one of my favorite places on earth. I usually try to head up there at least 3 times a year.